I've taken them on and off for many years. I have always had a taper at the end of a high dose, even going down to 1 mg for the last week or so. I suppose it depends on what you have them for. Mine is usually a flare up of arthritis or Crohn's. When on a high dose, I'm wide awake 23 hours a day and laugh a lot. I don't think I've ever been aggressive whilst taking them, nobody has ever mentioned that to me. My skin is dreadful, I bruise easily and get acne from time to time. It's also very thin and dry regardless how much moisturiser I use. I think that is the worst long term side effect I'm left with. I also don't sleep well.