With extra guests some people don't want the maid to come around and clean the room for fear of being "caught" - it doesn't really matter because she isn't going to interrogate you and she wouldn't know if all four of you were staying in the same room or if just two of you are and the other two are visiting from next door/down the hall/another hotel/etc
That said, if you don't want the maids to come around at all a suggestion would be to bring extra stuff along accordingly: the room is only going to have one spare roll of toilet paper plus whats on the holder so you might want to bring along an extra roll or two from home. Same would go for the toiletries like soap and shampoo: from
Excalibur its a little bit of a ways to go to get to a store where you can replace that stuff so you might want to bring along some extra from home.
If you are bringing along suitcases and people will have trouble being under the sheets with another person then you might also want to pack along things like a small blanket or an extra pillow in case there aren't enough in the room. If sleeping arrangements are going to be a major problem for some (IE: they just will not share a bed with anybody) you can buy a cheap pool mattress and bring that along for sleeping on the floor - the ones made for the pool won't be as good as an actual inflatable mattress, but they will make do for a couple of days, they are cheap ($5-7 usually) and they are light and take up less room than an inflatable mattress and you can just leave it behind in the room at the end of the trip.
Otherwise the only issue you might have is if somebody loses their key and they aren't one of the registered guests - they'll have to wait or find somebody to get let back in to the room.
When going down to the pool your key is good for you and a guest so if there are four of you and you only had two keys that'll still be enough for all of you to get in at once.
For any interactions you may have with staff, unless you tell them they won't know if you are staying together in one room or not - its not uncommon for groups to go to Las Vegas and meet up and stuff.